Why does lipedema develop? – Understanding the causes to better understand your body

The exact causes of lipedema are not yet fully scientifically clarified. A hormonal influence is considered certain: Lipedema occurs almost exclusively in women – mostly during phases of hormonal change such as puberty, pregnancy, or menopause. A genetic predisposition also seems to play a role, as several female family members are often affected.

Lipedema flares – i.e., acute worsening of symptoms – are often triggered by hormonal changes such as pregnancy, changes in hormonal contraception, or menopause. Weight gain, lack of exercise, or stress can also intensify symptoms such as tenderness, increased circumference, or pain. Early therapy helps to mitigate flares and slow down progression.

A single hormone as the sole cause is not known. Rather, an imbalance between estrogen and progesterone seems to be crucial – especially during sensitive life stages. These hormones influence adipose and connective tissue and contribute to the disproportionate proliferation of lipedema cells. Therefore, lipedema affects almost exclusively women.

The body is not lacking any specific nutrient in lipedema – it is not a classic deficiency state. Rather, the adipose tissue is pathologically altered: It reacts hypersensitively to hormonal stimuli, stores excessive fat, and is prone to inflammation. A low-inflammatory diet and micronutrient optimization can be supportive – but do not replace medical treatment.